Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 15/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687501 | 0.87 | GPR119 (0.52) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7298045 | 0.86 | GPR119 (0.63) | GPR119PDE3BPDE3APDE4B | |
| SCHEMBL7296347 | 0.84 | GPR119 (0.49) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7296587 | 0.83 | GPR119 (0.57) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7335403 | 0.82 | GPR119 (0.56) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7299065 | 0.81 | PDE3B (0.55) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9687674 | 0.80 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9686825 | 0.79 | GPR119 (0.46) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7304257 | 0.79 | GPR119 (0.51) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7298414 | 0.79 | GPR119 (0.51) | GPR119PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |