Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.32 |
| ▸ | GABRP | O00591 | 3/20 | 0.31 |
| ▸ | GABRD | O14764 | 3/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.31 |
| ▸ | GABRE | P78334 | 3/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.31 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.31 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CBFB | Q13951 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687853 | 0.87 | MEN1 (0.36) | OPRL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10375472 | 0.85 | GABRA1 (0.43) | OPRL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9688595 | 0.84 | OPRL1 (0.37) | OPRL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10376617 | 0.83 | PLAT (0.35) | OPRL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9534379 | 0.82 | MAPT (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9688097 | 0.81 | MAPT (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10375466 | 0.80 | OPRL1 (0.36) | OPRL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7491336 | 0.78 | GABRP (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9688545 | 0.78 | GABRA1 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9535569 | 0.73 | GABRA1 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |
| US-4960777-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | claimed |
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |
| US-4960777-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | disclosed |
| US-4877792-A | ANXIOLYTIC AGENTS; ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-31 | — | — | US | disclosed |