Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687582 | 0.90 | HPGD (0.50) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL10474647 | 0.89 | MTNR1A (0.41) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL9688077 | 0.84 | HPGD (0.46) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL9688674 | 0.82 | HRH3 (0.47) | TP53MAPTHDAC1HDAC6 | |
| SCHEMBL9688594 | 0.82 | TP53 (0.45) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL9688700 | 0.81 | ALDH1A1 (0.41) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL9687685 | 0.81 | HDAC1 (0.45) | HPGDKMT2AMEN1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL9689421 | 0.80 | HRH3 (0.48) | HDAC1HDAC6 | |
| SCHEMBL9689143 | 0.77 | ESRRG (0.42) | KMT2AMEN1ALDH1A1TP53MAPT | |
| Hydrochloric Acid SCHEMBL9688647 | 0.77 | ESRRG (0.41) | KMT2AMEN1ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | disclosed |