Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9687468 | 0.98 | ACHE (0.47) | NAMPTACHEKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL9687685 | 0.87 | HDAC1 (0.45) | KMT2AHPGDHDAC1TP53MAPT | |
| SCHEMBL9689143 | 0.87 | ESRRG (0.42) | ACHEKMT2ASMN1; SMN2NPC1HDAC1 | |
| Hydrochloric Acid SCHEMBL9688647 | 0.86 | ESRRG (0.41) | ACHEKMT2ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL9687505 | 0.85 | ACHE (0.44) | NAMPTACHEKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL9688632 | 0.83 | RAB9A (0.52) | KMT2ASMN1; SMN2NPC1LMNATP53 | |
| SCHEMBL10377746 | 0.81 | CA12 (0.40) | KMT2AHDAC1LMNATP53MAPT | |
| SCHEMBL10377910 | 0.81 | ALDH1A1 (0.39) | NAMPTKMT2ASMN1; SMN2NPC1HPGD | |
| Hydrochloric Acid SCHEMBL10644127 | 0.81 | NAMPT (0.37) | NAMPTKMT2ASMN1; SMN2NPC1HPGD | |
| Hydrochloric Acid SCHEMBL10575065 | 0.81 | CA12 (0.39) | KMT2AHDAC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |