Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587529 | 0.83 | HSD17B10 (0.59) | POLBHSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL4419943 | 0.81 | POLB (0.57) | POLBLTB4RPDE4BMTNR1AHSD17B10 | |
| SCHEMBL11264258 | 0.80 | POLB (0.45) | POLBPDE4BHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL24483184 | 0.80 | KMT2A (0.62) | POLBLTB4RPDE4BMTNR1AHSD17B10 | |
| SCHEMBL27788117 | 0.80 | POLB (0.60) | POLBPDE4BMTNR1AHSD17B10MTNR1B | |
| SCHEMBL23386065 | 0.80 | POLB (0.65) | POLBPDE4BMTNR1AHSD17B10ALDH1A1 | |
| SCHEMBL10767355 | 0.79 | POLB (0.56) | POLBLTB4RPDE4BHSD17B10ALDH1A1 | |
| SCHEMBL8714213 | 0.79 | POLB (0.56) | POLBLTB4RPDE4BHSD17B10ALDH1A1 | |
| SCHEMBL11080245 | 0.79 | POLB (0.59) | POLBLTB4RPDE4BMTNR1AHSD17B10 | |
| SCHEMBL11433418 | 0.79 | HSD17B10 (0.67) | POLBMTNR1AHSD17B10MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0179855-B1 | DOPAMINE AGONISTS | Whitby Research Incorporated (US) | 1992-07-29 | — | — | EP | disclosed |
| EP-0179855-A4 | DOPAMINE AGONISTS. | NELSON RES & DEV COMPANY (US) | 1986-08-21 | — | — | EP | disclosed |
| EP-0179855-A1 | DOPAMINE AGONISTS. | NELSON RES & DEV (US) | 1986-05-07 | — | — | EP | disclosed |
| WO-1985004582-A1 | NOVEL DOPAMINE AGONISTS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1985-10-24 | — | — | WO | disclosed |
| US-4540691-A | Dopamine agonists and use thereof | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1985-09-10 | — | — | US | disclosed |