Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9687737 | 1.00 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Oxalic Acid SCHEMBL9630637 | 0.88 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Oxalic Acid SCHEMBL9630643 | 0.88 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Fumaric Acid SCHEMBL9879661 | 0.86 | MEN1 (0.40) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL9630536 | 0.86 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL9687066 | 0.84 | RET (0.39) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL9629492 | 0.84 | MEN1 (0.41) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Fumaric Acid SCHEMBL9879818 | 0.84 | MEN1 (0.39) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL9688954 | 0.84 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTTP53 | |
| Oxalic Acid SCHEMBL9807288 | 0.83 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |