SCHEMBL9687919

SCHEMBL9687919

COc1ccnc(CSc2nc3c(C)c(OC(F)(F)C(F)Cl)c(C)cc3[nH]2)c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
RAB9A P51151 1/20 0.46
ATP4A P20648 8/20 0.41
ATP4B P51164 8/20 0.41
ATP1A1 P05023 7/20 0.41
ATP1B1 P05026 7/20 0.41
ATP1A3 P13637 7/20 0.41
ATP1B2 P14415 7/20 0.41
ATP1A2 P50993 7/20 0.41
ATP1B3 P54709 7/20 0.41
FXYD2 P54710 7/20 0.41
ATP1A4 Q13733 7/20 0.41
BRS3 P32247 1/20 0.39
ENPP1 P22413 5/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9686676 0.86 CYP3A4 (0.46) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9688799 0.84 NOS2 (0.50) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9687832 0.82 CYP1A2 (0.53) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9686687 0.81 ATP4A (0.40) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL9687791 0.79 ATP4A (0.44) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9688506 0.78 ATP4A (0.47) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9686799 0.77 CYP2C9 (0.45) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9793565 0.77 BRS3 (0.53) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9687828 0.77 ATP4A (0.47) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9526786 0.77 CYP1A2 (0.55) NPC1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0201575-B1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1992-08-12 EP disclosed
US-4686230-A Picoline derivative useful as gastric acid secretion inhibitors BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1987-08-11 US disclosed
EP-0201575-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM. BYK GULDEN LOMBERG CHEM FAB (DE) 1986-11-20 EP disclosed
WO-1986002646-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT M (DE) 1986-05-09 WO disclosed