Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936719 | 0.78 | ERCC5 (0.46) | ERCC5FEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL21440264 | 0.77 | ERCC5 (0.41) | ERCC5FEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL27374178 | 0.77 | ERCC5 (0.41) | ERCC5FEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL24662981 | 0.71 | ALDH1A1 (0.39) | HPGDKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8256708 | 0.69 | TSHR (0.47) | ERCC5FEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1135687 | 0.69 | HPGD (0.42) | ERCC5FEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL1548146 | 0.68 | HPGD (0.44) | ERCC5FEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL4743346 | 0.68 | ESR1 (0.42) | ERCC5FEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL1029641 | 0.68 | HPGD (0.47) | ERCC5FEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL31135508 | 0.68 | HPGD (0.47) | ERCC5FEN1HPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166180-A | Administering diphenyl substituted (thio)carbonyl(thio)urea derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-11-24 | — | — | US | disclosed |
| EP-0324521-A2 | Method of treating haematologic diseases and pharmaceutical compositions to be used therefor | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1989-07-19 | — | — | EP | disclosed |