Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689304 | 0.83 | POLB (0.32) | POLB | |
| SCHEMBL9688103 | 0.79 | PTPN1 (0.34) | PTPN1CDC25BLMNA | |
| SCHEMBL16174766 | 0.78 | PTPN1 (0.39) | PTPN1ACP1CDC25BTSHRNPSR1 | |
| SCHEMBL16174801 | 0.76 | LMNA (0.42) | PTPN1ACP1CDC25BTSHRNPSR1 | |
| SCHEMBL16174721 | 0.76 | PTPN1 (0.38) | PTPN1ACP1CDC25BTSHRNPSR1 | |
| SCHEMBL892475 | 0.75 | TSHR (0.39) | PTPN1TSHRLMNAKDM4EPOLB | |
| SCHEMBL22272451 | 0.72 | PTPN1 (0.50) | PTPN1ACP1CDC25BTSHRNPSR1 | |
| SCHEMBL8053864 | 0.71 | PTPN1 (0.42) | PTPN1ACP1CDC25BTSHRNPSR1 | |
| SCHEMBL5048212 | 0.68 | SIRT2 (0.35) | PTPN1ACP1CDC25B | |
| SCHEMBL16175075 | 0.66 | MMP2 (0.48) | PTPN1ACP1CDC25BTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |