Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.43 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.42 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9133693 | 0.98 | OPRK1 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL9366139 | 0.98 | OPRK1 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL9366144 | 0.98 | OPRK1 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL9361129 | 0.92 | DRD3 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL9362347 | 0.92 | DRD3 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL3144639 | 0.92 | DRD3 (0.62) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL5661590 | 0.83 | CYP19A1 (0.61) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL31541205 | 0.81 | CYP19A1 (0.60) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL630379 | 0.81 | CYP19A1 (0.60) | OPRK1CYP19A1DRD2DRD3CYP26A1 | |
| SCHEMBL6156864 | 0.79 | CYP19A1 (0.57) | OPRK1CYP19A1DRD2DRD3CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130339-A | Intestine and uterine motility modulators for reduction of intraocular pressure for glaucoma treatment | SANOFI (FR) | 1992-07-14 | — | — | US | disclosed |