Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.43 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370362 | 0.92 | KCNN2 (0.41) | KCNN2KCNN3KCNN1ALDH1A1MAOA | |
| SCHEMBL11220460 | 0.92 | KCNN2 (0.44) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 | |
| SCHEMBL10990476 | 0.92 | KCNN2 (0.41) | KCNN2KCNN3KCNN1ALDH1A1MAOA | |
| SCHEMBL11217845 | 0.90 | KCNN2 (0.43) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 | |
| SCHEMBL11224064 | 0.89 | HTR2C (0.45) | ALDH1A1TAAR1 | |
| SCHEMBL7290833 | 0.88 | ALDH1A1 (0.43) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 | |
| SCHEMBL11222930 | 0.87 | HTR2A (0.47) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 | |
| SCHEMBL7376032 | 0.84 | NQO2 (0.43) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 | |
| SCHEMBL11222498 | 0.83 | KCNN2 (0.42) | KCNN2KCNN3KCNN1ALDH1A1MAOA | |
| SCHEMBL11668404 | 0.83 | SIGMAR1 (0.42) | KCNN2KCNN3KCNN1ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |
| EP-0157206-A2 | Substituted isochromanes and oxepines, their acid addition salts, medicines containing them and process for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1985-10-09 | — | — | EP | disclosed |
| US-4352805-A | BENZOXEPINE DERIVATIVES | THE UPJOHN COMPANY (US) | 1982-10-05 | — | — | US | disclosed |
| US-4351942-A | Isochromans | AMERICAN HOME PRODUCTS CORP. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4312868-A | HYPOTENSIVE, ANTIPSYCHOTIC | THE UPJOHN COMPANY (US) | 1982-01-26 | — | — | US | disclosed |
| US-4251526-A | HYPOTENSIVE AGENTS AND ANTIPSYCHOTIC | PHARMACIA & UPJOHN COMPANY | 1981-02-17 | — | — | US | disclosed |
| US-4223151-A | 4-(6,7-DIMETHOXY-1-METHYL-ISOCHROMAN-1-YL)PYRIDINE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-09-16 | — | — | US | disclosed |
| US-4207239-A | HYPOTENSIVE, ANTIPSYCHOTIC | THE UPJOHN COMPANY (US) | 1980-06-10 | — | — | US | disclosed |
| US-4206123-A | INTERMEDIATES FOR HYPOTENSIVES | MCCALL JOHN M (US) | 1980-06-03 | — | — | US | disclosed |
| US-4181665-A | INTERMEDIATES FOR AMINO DERIVATIVES POSSESSING HYPOTENSIVE AND CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1980-01-01 | — | — | US | disclosed |
| US-4179510-A | ISOCHROMANS AND 2-BENZOXEPINS | THE UPJOHN COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4166062-A | HYPOTENSIVE AGENTS, CNS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-08-28 | — | — | US | disclosed |
| US-4153612-A | 2-Benzoxepins | THE UPJOHN COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4066648-A | ANTIDEPRESSANTS, ANALGESICS, DIURETICS, ANTIINFLAMMATORY AGENTS, MUSCLE RELAXANTS, VASODIALATORS, HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1978-01-03 | — | — | US | disclosed |
| US-4036842-A | FRIEDEL CRAFTS CATALYST | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-07-19 | — | — | US | disclosed |
| US-4021451-A | P-(3,4-DIHYDRO-1-METHYL-1H-(1)BENZOTHIENO(2,3-C)PYRAN-1-YL)PHENYL) -ACETIC ACID | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-05-03 | — | — | US | disclosed |