Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314946 | 0.72 | ALDH1A1 (0.33) | MAPK1 | |
| SCHEMBL16312316 | 0.69 | CYP1A2 (0.35) | MAPK1CYP1A2LMNACYP2C9 | |
| SCHEMBL11423451 | 0.66 | KMT2A (0.34) | — | |
| SCHEMBL13865681 | 0.63 | — | — | |
| SCHEMBL14112926 | 0.63 | — | — | |
| SCHEMBL6114 | 0.62 | — | — | |
| SCHEMBL16508860 | 0.61 | CPB2 (0.51) | CYP2C9 | |
| Hydrochloric Acid SCHEMBL2210811 | 0.60 | — | — | |
| SCHEMBL2355348 | 0.60 | — | — | |
| SCHEMBL8573707 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329357-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-07-15 | — | — | EP | disclosed |
| EP-0329357-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1989-08-23 | — | — | EP | disclosed |
| US-4859686-A | Dihydropyridine anti-allergic and anti-inflammatory agents | PFIZER INC. (US) | 1989-08-22 | — | — | US | disclosed |