SCHEMBL9689020

SCHEMBL9689020

CS(=O)(=O)OCCCc1ccc2c(c1)OCO2

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.50
CALM1 P0DP23 3/20 0.49
HDAC1 Q13547 2/20 0.48
HDAC3 O15379 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
CYP3A4 P08684 1/20 0.48
TRPV1 Q8NER1 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MMP1 P03956 1/20 0.44
MMP7 P09237 1/20 0.44
MMP8 P22894 1/20 0.44
MMP12 P39900 1/20 0.44
MMP13 P45452 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24045389 0.91 MAOA (0.48) MAOAMAOBSMN1; SMN2
SCHEMBL2798211 0.91 TAAR1 (0.53) TAAR1CALM1MAOAMAOBCYP3A4
SCHEMBL3809994 0.86 TAAR1 (0.48) TAAR1CALM1CYP3A4SMN1; SMN2MMP1
SCHEMBL5746370 0.82 SMN1; SMN2 (0.45) TAAR1MAOAMAOBSMN1; SMN2
SCHEMBL1680936 0.82 CYP3A4 (0.60) TAAR1CALM1CYP3A4SMN1; SMN2
SCHEMBL30408858 0.79 SMN1; SMN2 (0.51) HDAC1HDAC3HDAC2HDAC6HDAC8
SCHEMBL108050 0.78 CALM1 (0.72) TAAR1CALM1HDAC1HDAC3HDAC2
SCHEMBL9153832 0.77 MMP1 (0.59) TAAR1CALM1CYP3A4MMP1MMP7
SCHEMBL27474367 0.77 TAAR1 (0.53) TAAR1CALM1HDAC1HDAC3HDAC2
SCHEMBL9748430 0.75 MAOB (0.61) MAOAMAOBCYP3A4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120843-A Nervous system disorders UPJOHN (US) 1992-06-09 US disclosed
EP-0487510-A1 Pharmaceutically active amines THE UPJOHN COMPANY (US) 1992-05-27 EP disclosed
EP-0358676-A1 PHARMACEUTICALLY ACTIVE AMINES THE UPJOHN COMPANY (US) 1990-03-21 EP disclosed
EP-0293078-A1 Pharmaceutically active amines THE UPJOHN COMPANY (US) 1988-11-30 EP disclosed
WO-1988008424-A1 PHARMACEUTICALLY ACTIVE AMINES THE UPJOHN COMPANY (US) 1988-11-03 WO disclosed