Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Carbamic Acid Phenyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid Phenyl Ester SCHEMBL9689363 | 1.00 | MEN1 (0.57) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| Carbamic Acid Phenyl Ester SCHEMBL7566 | 0.89 | MEN1 (0.70) | MEN1KMT2AKDM4EPARP10ATM | |
| Carbamic Acid Phenyl Ester SCHEMBL11627152 | 0.87 | MEN1 (0.67) | MEN1KMT2AKDM4ESMN1; SMN2HDAC6 | |
| Carbamic Acid Phenyl Ester SCHEMBL17144965 | 0.87 | MEN1 (0.67) | MEN1KMT2AKDM4ESMN1; SMN2HDAC6 | |
| Carbamic Acid Phenyl Ester SCHEMBL28935973 | 0.87 | MEN1 (0.67) | MEN1KMT2AKDM4ESMN1; SMN2HDAC6 | |
| Carbamic Acid Phenyl Ester SCHEMBL11792763 | 0.87 | MEN1 (0.67) | MEN1KMT2AKDM4ESMN1; SMN2HDAC6 | |
| Carbamic Acid Phenyl Ester SCHEMBL5447519 | 0.87 | MEN1 (0.67) | MEN1KMT2AKDM4ESMN1; SMN2HDAC6 | |
| Carbamic Acid Phenyl Ester SCHEMBL3412977 | 0.86 | MEN1 (0.55) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| Phenyl Fumarate SCHEMBL528592 | 0.83 | HCAR2 (0.55) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| Phenyl Fumarate SCHEMBL529210 | 0.83 | HCAR2 (0.55) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |