Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 4/20 | 0.40 |
| ▸ | GABRP | O00591 | 3/20 | 0.40 |
| ▸ | GABRD | O14764 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.40 |
| ▸ | GABRE | P78334 | 3/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688616 | 0.85 | GABRA1 (0.54) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9687656 | 0.84 | GABRP (0.41) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9688273 | 0.79 | GABRP (0.50) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9688661 | 0.77 | GABRA1 (0.47) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9687594 | 0.76 | GABRA1 (0.68) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9688590 | 0.76 | GABRA5 (0.49) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9689355 | 0.76 | GABRA1 (0.57) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8849695 | 0.73 | GABRA1 (0.56) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9689324 | 0.72 | GABRA1 (0.67) | GABRA5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9688108 | 0.71 | GABRA1 (0.50) | GABRA5GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |
| US-4877792-A | ANXIOLYTIC AGENTS; ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-31 | — | — | US | disclosed |