Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690480 | 0.87 | NPC1 (0.46) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL9688308 | 0.84 | NPC1 (0.40) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL29703262 | 0.73 | NPC1 (0.63) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL10044417 | 0.73 | NPC1 (0.62) | NPC1RAB9AMITFPKMTDP1 | |
| Hydrochloric Acid SCHEMBL9689680 | 0.72 | SIGMAR1 (0.51) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL9689620 | 0.71 | NPC1 (0.54) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL9630022 | 0.71 | GFER (0.54) | TDP1L3MBTL1MAPK1 | |
| SCHEMBL13861649 | 0.70 | NPC1 (0.59) | NPC1RAB9AMITFPKMTDP1 | |
| Hydrochloric Acid SCHEMBL9690298 | 0.70 | KCNH2 (0.47) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL7862743 | 0.70 | NPC1 (0.62) | NPC1RAB9AMITFPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |