Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859998 | 0.86 | KDM4E (0.65) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL21995802 | 0.83 | KMT2A (0.47) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL2759541 | 0.81 | ALDH1A1 (0.53) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL24348727 | 0.79 | DPP4 (0.63) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL20138279 | 0.79 | KDM4E (0.51) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL859623 | 0.79 | ALDH1A1 (0.51) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL16156201 | 0.79 | KMT2A (0.58) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL6491197 | 0.78 | ENPP2 (0.60) | KDM4EKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL13341899 | 0.78 | NPC1 (0.55) | KDM4EALDH1A1GAAHSD17B10HTT | |
| SCHEMBL13348090 | 0.77 | KDM4E (0.45) | KDM4EKMT2AALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294074-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1992-04-08 | — | — | EP | disclosed |
| US-4851412-A | ASTHMA, ARTHRITIS | PFIZER INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0294074-A1 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-12-07 | — | — | EP | disclosed |