Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 17/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 17/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 11/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 11/20 | 0.56 |
| ▸ | GABRP | O00591 | 3/20 | 0.56 |
| ▸ | GABRD | O14764 | 3/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.56 |
| ▸ | GABRE | P78334 | 3/20 | 0.56 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.56 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.56 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688204 | 0.89 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9689016 | 0.86 | FPR2 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9688147 | 0.85 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9689307 | 0.81 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7380810 | 0.79 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL10388941 | 0.74 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7380799 | 0.73 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL10405046 | 0.73 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9687760 | 0.72 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2353190 | 0.72 | GABRA1 (0.75) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |
| US-4960777-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | disclosed |
| US-4877792-A | ANXIOLYTIC AGENTS; ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-31 | — | — | US | disclosed |