Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630899 | 0.91 | OPRM1 (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3733641 | 0.84 | CCR5 (0.62) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6196424 | 0.79 | RPS6KB1 (0.58) | OPRM1OPRK1OPRD1OPRL1CYP2D6 | |
| SCHEMBL21148134 | 0.79 | RPS6KB1 (0.58) | OPRM1OPRK1OPRD1OPRL1CYP2D6 | |
| SCHEMBL2929873 | 0.79 | RPS6KB1 (0.58) | OPRM1OPRK1OPRD1OPRL1OGFRL1 | |
| SCHEMBL6198016 | 0.79 | RPS6KB1 (0.58) | OPRM1OPRK1OPRD1OPRL1CYP2D6 | |
| SCHEMBL6196431 | 0.79 | RPS6KB1 (0.58) | OPRM1OPRK1OPRD1OPRL1CYP2D6 | |
| SCHEMBL21311255 | 0.77 | OPRM1 (0.59) | OPRM1OPRK1OPRD1OPRL1OGFRL1 | |
| SCHEMBL14826124 | 0.77 | OGFRL1 (0.47) | OPRM1OPRK1OPRD1CYP2D6CCR5 | |
| SCHEMBL12598295 | 0.77 | BRD4 (0.63) | OPRM1OPRK1OPRD1OPRL1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |