Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | THPO | P40225 | 2/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691974 | 0.95 | HSD17B10 (0.54) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL9824964 | 0.87 | CACNA1C (0.49) | MAPTHIF1ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10689136 | 0.85 | HSD17B10 (0.51) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL7287257 | 0.84 | ADORA3 (0.53) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL10488355 | 0.84 | ADORA3 (0.53) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL10922862 | 0.83 | CACNA1C (0.52) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL9789920 | 0.83 | ADORA3 (0.52) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL10488517 | 0.83 | ADORA3 (0.53) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL7347116 | 0.82 | HSD17B10 (0.56) | HSD17B10MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL9672729 | 0.82 | CACNA1F (0.68) | MAPTHIF1ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0194751-B1 | DIHYDROPYRIDINE ALKANOL AMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-4873254-A | ADRENERGIC BLOCKING AGENTS OR CALCIUM CHANNEL BLOCKERS; HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-10-10 | — | — | US | disclosed |
| EP-0194047-A1 | Dihydropyridine alkanol amines, process for their preparation and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-09-10 | — | — | EP | disclosed |