Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689854 | 0.95 | HSD17B10 (0.50) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL7347116 | 0.85 | HSD17B10 (0.56) | HSD17B10LMNAHIF1AMAPTKMT2A | |
| SCHEMBL10691979 | 0.84 | LMNA (0.61) | HSD17B10LMNAALDH1A1AGTR1RAB9A | |
| SCHEMBL9825000 | 0.83 | ADORA3 (0.54) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL10488517 | 0.82 | ADORA3 (0.53) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL10692951 | 0.82 | ADORA3 (0.53) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL9824964 | 0.82 | CACNA1C (0.49) | LMNAALDH1A1RAB9AHIF1AMAPT | |
| SCHEMBL10488355 | 0.81 | ADORA3 (0.53) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL7406051 | 0.81 | ADORA3 (0.53) | HSD17B10LMNAALDH1A1AGTR1HIF1A | |
| SCHEMBL7287257 | 0.81 | ADORA3 (0.53) | HSD17B10LMNAALDH1A1AGTR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |
| US-4727082-A | CARDIOVASCULAR DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| EP-0167371-A2 | Dihydropyridine compounds, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-01-08 | — | — | EP | disclosed |