SCHEMBL9690085

SCHEMBL9690085

COc1cc(C2C(C(=O)O)=C(C)NC(C)=C2C(=O)O)cc(OC)c1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.51
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA3 P07451 1/20 0.51
CA4 P22748 1/20 0.51
CA6 P23280 1/20 0.51
CA5A P35218 1/20 0.51
CA7 P43166 1/20 0.51
CA9 Q16790 1/20 0.51
CA14 Q9ULX7 1/20 0.51
CA5B Q9Y2D0 1/20 0.51
PTGS2 P35354 2/20 0.45
GAA P10253 7/20 0.44
TSHR P16473 1/20 0.44
HTT P42858 1/20 0.44
LMNA P02545 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
TP53 P04637 1/20 0.42
ALDH1A1 P00352 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9690101 0.89 KMT2A (0.43) GAATSHRLMNAL3MBTL1ALDH1A1
SCHEMBL9473905 0.84 ALDH1A1 (0.51) CA12CA1CA2CA4CA6
SCHEMBL9688157 0.82 KDM4E (0.49) GAATSHRHTTLMNAALDH1A1
SCHEMBL9685002 0.76 GLRA3 (0.46) CA1CA2PTGS2GAATSHR
SCHEMBL27517088 0.75 KDM4E (0.68) CA1CA2GAATSHRHTT
SCHEMBL10564440 0.74 CACNA1F (0.61) GAATP53ALDH1A1KDM4EHPGD
SCHEMBL9806975 0.73 MAPT (0.56) PKMCA12CA1CA2CA7
SCHEMBL7818687 0.73 GAA (0.67) CA2GAATSHRHTTL3MBTL1
SCHEMBL30932230 0.73 ALDH1A1 (0.64) GAATSHRHTTLMNATP53
SCHEMBL4647285 0.72 GAA (0.60) PKMGAATSHRHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0158211-B1 1,4-DIHYDROPYRIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USES AS MEDICAMENTS LABORATORIOS DELAGRANGE S.A. (ES) 1992-08-26 EP disclosed
US-4722931-A MUSCLE RELAXANTS LABORATORIOS DELAGRANGE (ES) 1988-02-02 US disclosed
EP-0158211-A2 1,4-Dihydropyridin derivatives, process for their preparation and their uses as medicaments LABORATORIOS DELAGRANGE S.A. (ES) 1985-10-16 EP disclosed