Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7328648 | 0.93 | LMNA (0.56) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| Hydrochloric Acid SCHEMBL7336927 | 0.90 | HRH1 (0.44) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| SCHEMBL7335483 | 0.87 | USP2 (0.54) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| Hydrochloric Acid SCHEMBL7335128 | 0.83 | ALOX5 (0.46) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| SCHEMBL10365792 | 0.81 | CYP3A4 (0.58) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| SCHEMBL9690451 | 0.81 | TSHR (0.49) | DRD3SLC6A3CYP3A4OPRM1TSHR | |
| SCHEMBL8538110 | 0.81 | TSHR (0.44) | DRD3SLC6A3CYP3A4USP2OPRM1 | |
| SCHEMBL9689567 | 0.80 | CYP3A4 (0.63) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| SCHEMBL10648165 | 0.79 | USP2 (0.50) | HRH1DRD3SLC6A3HTR2BCYP3A4 | |
| SCHEMBL7336256 | 0.78 | MAPT (0.46) | HRH1DRD3SLC6A3HTR2BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |