Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 7/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.36 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530581 | 0.79 | TDP1 (0.56) | ALDH1A1MAPTMDM2POLBTP53 | |
| SCHEMBL9339112 | 0.77 | MAPT (0.49) | ALDH1A1KDM4EMAPTHTTBRS3 | |
| SCHEMBL4432510 | 0.73 | KDM4E (0.49) | ALDH1A1KDM4ELMNAMAPTPOLB | |
| SCHEMBL9337484 | 0.71 | MAPT (0.46) | ALDH1A1KDM4EHPGDMAPTHTT | |
| SCHEMBL1837211 | 0.69 | ALDH1A1 (0.51) | ALDH1A1HPGDHSD17B10KDM4A | |
| SCHEMBL4429436 | 0.69 | KDM4E (0.53) | ALDH1A1KDM4EMAPTHSD17B10GPR84 | |
| SCHEMBL28058117 | 0.68 | ESR1 (0.61) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL4430955 | 0.68 | KDM4E (0.47) | ALDH1A1KDM4ELMNAHTTKDM6B | |
| SCHEMBL9571043 | 0.68 | MAPT (0.40) | ALDH1A1KDM4EHPGDMAPTHTT | |
| SCHEMBL28087839 | 0.68 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1068109-A | New angiotension II antagonists and the preparation of preparation and application | FISONS PLC (GB) | 1993-01-20 | — | — | CN | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |