Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337181 | 0.80 | KDM4E (0.55) | TDP1L3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL949772 | 0.80 | NPC1 (0.51) | TDP1L3MBTL1TSHRALDH1A1MAPK1 | |
| SCHEMBL9690183 | 0.79 | ALDH1A1 (0.45) | ALDH1A1POLBMAPTMDM2TP53 | |
| SCHEMBL27477137 | 0.79 | TDP1 (0.46) | TDP1L3MBTL1TSHRALDH1A1MAPK1 | |
| SCHEMBL9339112 | 0.78 | MAPT (0.49) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9339127 | 0.78 | TNKS (0.45) | L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL8884936 | 0.77 | GPR84 (0.50) | TDP1L3MBTL1TSHRALDH1A1MAPK1 | |
| SCHEMBL9341393 | 0.76 | TSHR (0.42) | TSHRALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL1232508 | 0.76 | ALDH1A1 (0.69) | TDP1L3MBTL1TSHRALDH1A1MAPK1 | |
| SCHEMBL4429436 | 0.75 | KDM4E (0.53) | TDP1TSHRALDH1A1CYP3A4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| CN-1068109-A | New angiotension II antagonists and the preparation of preparation and application | FISONS PLC (GB) | 1993-01-20 | — | — | CN | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |