Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KDM6B | O15054 | 6/20 | 0.44 |
| ▸ | KDM4A | O75164 | 6/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 6/20 | 0.44 |
| ▸ | HIF1AN | Q9NWT6 | 6/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.44 |
| ▸ | KDM3B | Q7LBC6 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432510 | 0.85 | KDM4E (0.49) | KDM4EHTR1BMTNR1AMTNR1BMTOR | |
| SCHEMBL4428193 | 0.80 | DAO (0.54) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL3912930 | 0.74 | KDM4E (0.53) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL9339112 | 0.73 | MAPT (0.49) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4428237 | 0.72 | KDM4E (0.50) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL2592545 | 0.72 | KDM4E (0.49) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4427252 | 0.71 | KDM4E (0.53) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL9337517 | 0.71 | KDM4E (0.45) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4433258 | 0.70 | KDM4E (0.55) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4428820 | 0.70 | KDM4E (0.47) | KDM4EKDM6BKDM4AKDM4DHIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |