Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 2/20 | 0.40 |
| ▸ | F3 | P13726 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690893 | 0.90 | KMT2A (0.49) | FABP3FABP4KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9689731 | 0.82 | HSD17B10 (0.48) | KMT2ALMNAMAPTMAPK1DYRK1A | |
| SCHEMBL9689816 | 0.73 | GABRP (0.54) | FABP3FABP4KMT2AMAPTEGFR | |
| SCHEMBL613136 | 0.72 | LMNA (0.51) | KMT2ASIRT1LMNAMAP2MAPT | |
| SCHEMBL9690098 | 0.71 | HSD17B10 (0.44) | KMT2ALMNAMAPTMAPK1DYRK1A | |
| SCHEMBL9690435 | 0.71 | GABRP (0.54) | FABP3FABP4KMT2A | |
| SCHEMBL4332943 | 0.69 | MAP2 (0.61) | KMT2ALMNAMAP2F7F3 | |
| SCHEMBL2372152 | 0.69 | LMNA (0.51) | KMT2ASIRT1LMNAMAP2MAPT | |
| SCHEMBL13596860 | 0.69 | KDM4E (0.46) | KMT2ASIRT1LMNAMAPTCYP1A2 | |
| SCHEMBL3037898 | 0.68 | MAP2 (0.63) | KMT2ASIRT1LMNAMAP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | claimed |
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4952584-A | TREATMENT OF PROPHYLAXIS OF ANXIETY OR DEPRESSION | BEECHAM GROUP P.L.C. (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | disclosed |