Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690597 | 0.82 | KDM4E (0.64) | NPC1RAB9ASMN1; SMN2GAALMNA | |
| SCHEMBL6240044 | 0.79 | NPC1 (0.63) | GPR55NPC1RAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL4109825 | 0.77 | SMN1; SMN2 (0.62) | NPC1RAB9ARXFP1SMN1; SMN2MAPK1 | |
| SCHEMBL443475 | 0.77 | KDM4E (0.73) | GPR55NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL14880019 | 0.77 | SMN1; SMN2 (0.62) | NPC1RAB9ARXFP1SMN1; SMN2HDAC1 | |
| SCHEMBL26570393 | 0.76 | BCAT1 (0.51) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL26577734 | 0.76 | ROCK2 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL2775855 | 0.75 | NPC1 (0.55) | GPR55NPC1RAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL443572 | 0.74 | HDAC1 (0.59) | GPR55NPC1RAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL4924298 | 0.74 | GPR55 (0.78) | GPR55NPC1RAB9ARXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |