Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.62 |
| ▸ | SSTR5 | P35346 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 3/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9630697 | 0.95 | EED (0.56) | EEDSSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9690828 | 0.86 | DRD2 (0.47) | EEDSSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9535893 | 0.84 | HTR1A (0.53) | EEDSSTR5KCNH2HRH1CACNA1F | |
| SCHEMBL9537908 | 0.83 | HTR1A (0.52) | EEDSSTR5KCNH2NR4A2HRH1 | |
| Fumaric Acid SCHEMBL9630652 | 0.81 | DRD2 (0.43) | EEDSSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9629452 | 0.80 | SSTR5 (0.91) | EEDSSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9629572 | 0.80 | DRD2 (0.46) | EEDSSTR5KCNH2HRH1CACNA1F | |
| SCHEMBL9741257 | 0.79 | SSTR5 (0.63) | EEDSSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9629523 | 0.78 | EED (0.74) | EEDSSTR5KCNH2NR4A2HRH1 | |
| Hydrochloric Acid SCHEMBL9631577 | 0.77 | EED (0.73) | EEDSSTR5KCNH2NR4A2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |