Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | HRH1 | P35367 | 6/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10551226 | 0.90 | DRD2 (0.52) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL10551137 | 0.90 | DRD2 (0.52) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9537863 | 0.87 | SSTR5 (0.45) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9535482 | 0.87 | DRD2 (0.54) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9537908 | 0.86 | HTR1A (0.52) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9537098 | 0.85 | HTR2A (0.49) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9383006 | 0.85 | SSTR5 (0.47) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9536711 | 0.84 | CYP2D6 (0.59) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9690928 | 0.84 | EED (0.62) | HTR1ADRD2HTR2AKCNH2HRH1 | |
| SCHEMBL9565008 | 0.82 | DRD2 (0.50) | HTR1ADRD2HTR2AKCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |