Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 19/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 19/20 | 1.00 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691872 | 0.85 | PDE3B (0.78) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9693445 | 0.80 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL9693383 | 0.79 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9692111 | 0.79 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9693701 | 0.79 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL9693319 | 0.78 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9691758 | 0.78 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9694200 | 0.77 | PDE3B (0.77) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9693683 | 0.76 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9691765 | 0.76 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | claimed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | claimed |
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |