Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 19/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 19/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.57 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691970 | 0.82 | NPC1 (0.56) | PDE3BPDE3AMAPTP2RY12PDE2A | |
| SCHEMBL7384334 | 0.77 | PDE3B (0.64) | PDE3BPDE3APOLBMAPTBLM | |
| SCHEMBL10758549 | 0.76 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL10077253 | 0.76 | MAPT (1.00) | POLBMAPTBLMTDP1 | |
| SCHEMBL31307805 | 0.76 | MAPT (1.00) | POLBMAPTBLMTDP1 | |
| SCHEMBL6740302 | 0.76 | MEN1 (0.69) | MAPT | |
| SCHEMBL9693347 | 0.73 | PDE3B (0.67) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL10757077 | 0.73 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL8943382 | 0.73 | PDE3B (0.70) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL10654057 | 0.73 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | claimed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | claimed |
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |