Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.56 |
| ▸ | PDE2A | O00408 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9692012 | 0.82 | PDE3B (0.62) | PDE3BPDE3APDE2AMAPTP2RY12 | |
| SCHEMBL8943438 | 0.81 | PDE3B (0.60) | RAB9APDE3BPDE3APDE2ASMN1; SMN2 | |
| SCHEMBL20772671 | 0.78 | MAPT (0.69) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL26597177 | 0.74 | MMP2 (0.76) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL30667671 | 0.74 | MMP2 (0.76) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8980359 | 0.74 | NPC1 (0.69) | NPC1RAB9APLAUMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL19149753 | 0.73 | MMP2 (0.74) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL31061086 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL2014813 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL11212351 | 0.73 | ABL1 (0.63) | NPC1RAB9APLAUMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | claimed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | claimed |
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |