Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.48 |
| ▸ | HTR2A | P28223 | 8/20 | 0.48 |
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678100 | 0.84 | KCNH2 (0.48) | KCNH2HTR2AHTR2CHTR1ASLC6A4 | |
| SCHEMBL9677488 | 0.71 | KCNH2 (0.55) | KCNH2HTR2AHTR2CALDH1A1CYP3A4 | |
| SCHEMBL9678360 | 0.71 | KCNH2 (0.69) | KCNH2HTR2AHTR2CDRD2HTR1A | |
| SCHEMBL9444367 | 0.70 | ABCB1 (0.61) | HTR1ASLC6A4ABCB1ALDH1A1LMNA | |
| SCHEMBL6585372 | 0.69 | KCNH2 (0.51) | KCNH2HTR2AHTR2CDRD2 | |
| SCHEMBL9681410 | 0.69 | ABCB1 (0.43) | KCNH2HTR1ASLC6A4ABCB1ALDH1A1 | |
| SCHEMBL9447564 | 0.68 | ABCB1 (0.45) | KCNH2HTR1ASLC6A4ABCB1ADRA1A | |
| SCHEMBL9041547 | 0.68 | ABCB1 (0.43) | KCNH2HTR1ASLC6A4ABCB1ALDH1A1 | |
| SCHEMBL7026059 | 0.68 | HTR2A (0.56) | KCNH2HTR2AHTR2CDRD2HTR1A | |
| SCHEMBL7022853 | 0.68 | HTR2A (0.52) | KCNH2HTR2AHTR2CADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |