SCHEMBL9693358

SCHEMBL9693358

COc1ccc(C(NC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)C[C@@H]2OP(O)N(CCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DUT P33316 9/20 0.51
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9693407 0.90 RNASE1 (0.40) DUT
SCHEMBL9342955 0.83 RNASE1 (0.42) DUT
SCHEMBL9693591 0.79 DUT (0.36) DUTMEN1KMT2A
SCHEMBL9342953 0.79 RNASE1 (0.44) DUT
SCHEMBL13463976 0.78 DUT (0.84) DUT
SCHEMBL9345125 0.78 DUT (0.84) DUT
SCHEMBL13444852 0.78 DUT (0.84) DUT
SCHEMBL19840575 0.76 DUT (0.43) DUTMEN1KMT2A
SCHEMBL2710677 0.76 RNASE1 (0.39) DUT
SCHEMBL8959002 0.75 DUT (0.42) DUTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5118800-A Oligonucleotides possessing a primary amino group in the terminal nucleotide CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1992-06-02 US disclosed
US-5015733-A Phosphoramidites and oligonucleotides derived therefrom CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1991-05-14 US disclosed
US-4849513-A Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1989-07-18 US disclosed