SCHEMBL9693407

SCHEMBL9693407

COc1ccc(C(NC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2OP(O)N(CCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.40
DUT P33316 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9342955 0.93 RNASE1 (0.42) RNASE1DUT
SCHEMBL9693358 0.90 DUT (0.51) DUT
SCHEMBL9342953 0.89 RNASE1 (0.44) RNASE1DUT
SCHEMBL2710677 0.86 RNASE1 (0.39) RNASE1DUT
SCHEMBL9341952 0.85 RNASE1 (0.46) RNASE1DUT
SCHEMBL152181 0.83 RNASE1 (0.48) RNASE1DUT
SCHEMBL2710682 0.83 RNASE1 (0.42) RNASE1DUT
SCHEMBL8655483 0.81 RNASE1 (0.42) RNASE1DUT
SCHEMBL9782837 0.79 RNASE1 (0.41) RNASE1
SCHEMBL7706053 0.79 RNASE1 (0.46) RNASE1DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5118800-A Oligonucleotides possessing a primary amino group in the terminal nucleotide CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1992-06-02 US disclosed
US-5015733-A Phosphoramidites and oligonucleotides derived therefrom CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1991-05-14 US disclosed
US-4849513-A Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1989-07-18 US disclosed