Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068098 | 0.88 | HTT (0.62) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL28229859 | 0.87 | HTT (0.57) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL9693982 | 0.84 | MAPT (0.52) | SMN1; SMN2LMNAKMT2AMEN1POLB | |
| SCHEMBL9693251 | 0.84 | ALDH1A1 (0.62) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL11526803 | 0.82 | HTT (0.71) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL17395911 | 0.81 | ALDH1A1 (0.47) | HTTLMNAKMT2APOLBMAPT | |
| SCHEMBL29952677 | 0.80 | HTT (0.60) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL358355 | 0.80 | HTT (0.63) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL18775437 | 0.80 | MAPK1 (0.49) | KMT2AMEN1POLBMAPTMAPK1 | |
| SCHEMBL10790188 | 0.80 | HTT (0.68) | HTTSMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |