SCHEMBL9694157

SCHEMBL9694157

COc1cc(Cn2c(=S)sc3ccccc32)cc(OC)c1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.54
LMNA P02545 1/20 0.54
HTT P42858 1/20 0.54
USP2 O75604 1/20 0.49
GLA P06280 1/20 0.49
SMN1; SMN2 Q16637 3/20 0.48
THRB P10828 1/20 0.48
GAA P10253 7/20 0.46
MAPT P10636 3/20 0.46
TP53 P04637 1/20 0.46
POLB P06746 3/20 0.45
MAPK1 P28482 1/20 0.45
MEN1 O00255 1/20 0.42
PSMD14 O00487 1/20 0.42
KMT2A Q03164 1/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
PKM P14618 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9694960 0.83 L3MBTL1 (0.42) TSHRLMNAHTTSMN1; SMN2GAA
SCHEMBL9694539 0.80 L3MBTL1 (0.46) TSHRLMNAHTTUSP2SMN1; SMN2
SCHEMBL9694402 0.80 L3MBTL1 (0.40) TSHRLMNAHTTUSP2GLA
SCHEMBL9694360 0.80 F2R (0.43) TSHRLMNAHTTSMN1; SMN2THRB
SCHEMBL9694747 0.78 L3MBTL1 (0.43) TSHRLMNAHTTSMN1; SMN2GAA
SCHEMBL9692922 0.77 TP53 (0.39) TSHRLMNAHTTUSP2GLA
SCHEMBL9694879 0.76 L3MBTL1 (0.50) TSHRLMNAHTTSMN1; SMN2GAA
SCHEMBL9814263 0.76 KDM4E (0.47) TSHRLMNAHTTSMN1; SMN2GAA
SCHEMBL9692934 0.76 DRD2 (0.46) TSHRLMNAHTTSMN1; SMN2MEN1
SCHEMBL9694390 0.76 F2R (0.39) TSHRLMNAHTTSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5169950-A Reacting a 2-mercaptobenzothiazole, acarbonyl and a phenol; basic catalyst; polar solvent CIBA-GEIGY CORPORATION (US) 1992-12-08 US disclosed
US-5097039-A Coating, lubricants CIBA-GEIGY CORPORATION (US) 1992-03-17 US disclosed
US-5069805-A OIL ADDITIVES CIBA-GEIGY CORPORATION (US) 1991-12-03 US disclosed
EP-0259254-B1 PHENOLIC BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS CORROSION INHIBITORS CIBA-GEIGY AG (CH) 1991-04-17 EP disclosed
US-4894091-A PROTECTIVE COATINGS, PHOTOSTABILIZERS, HEAT RESISTANCE CIBA-GEIGY CORPORATION (US) 1990-01-16 US disclosed
EP-0259254-A1 Phenolic benzothiazole derivatives and their use as corrosion inhibitors CIBA-GEIGY AG (CH) 1988-03-09 EP disclosed