Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11470280 | 0.91 | GAA (0.62) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL6337049 | 0.82 | GAA (0.59) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL2637278 | 0.81 | GAA (0.95) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL3388855 | 0.81 | GAA (0.64) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL5621969 | 0.79 | GAA (0.82) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL9045649 | 0.79 | GAA (0.82) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL28309852 | 0.78 | ALDH1A1 (0.77) | GAALMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL24011910 | 0.77 | GAA (0.78) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL9123832 | 0.77 | GAA (0.78) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL2561095 | 0.77 | L3MBTL1 (0.53) | MAPTHPGDSMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498770-A1 | Certain benzodioxole, benzodioxane and benzodioxepin derivatives | CIBA-GEIGY AG (CH) | 1992-08-12 | — | — | EP | disclosed |
| US-5120758-A | Treating allergic, inflammatory, cardiovascular, pulmonary, arthritic, cutaneous disorders | CIBA-GEIGY CORPORATION (US) | 1992-06-09 | — | — | US | disclosed |