Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697935 | 0.84 | SMN1; SMN2 (0.51) | TNKSHDAC6SMN1; SMN2USP2NOD1 | |
| Hydrochloric Acid SCHEMBL9697558 | 0.83 | SMN1; SMN2 (0.50) | TNKSHDAC6SMN1; SMN2USP2NOD1 | |
| SCHEMBL3360368 | 0.82 | TSHR (0.48) | NR3C2SMN1; SMN2USP2NOD1NOD2 | |
| Hydrochloric Acid SCHEMBL9697076 | 0.81 | TSHR (0.47) | NR3C2SMN1; SMN2USP2NOD1NOD2 | |
| SCHEMBL9697931 | 0.79 | NR3C2 (0.44) | HDAC6NR3C2HPGDCYP1A2CYP2D6 | |
| SCHEMBL9732994 | 0.79 | NPC1 (0.46) | SMN1; SMN2USP2NPC1RAB9ATP53 | |
| SCHEMBL9696959 | 0.78 | TSHR (0.47) | SMN1; SMN2USP2NOD1NOD2MAPT | |
| Hydrochloric Acid SCHEMBL9733674 | 0.78 | NPC1 (0.46) | SMN1; SMN2USP2NPC1RAB9ATP53 | |
| SCHEMBL9733161 | 0.78 | USP2 (0.40) | HDAC6NR3C2SMN1; SMN2USP2TP53 | |
| Hydrochloric Acid SCHEMBL9697582 | 0.77 | TSHR (0.46) | SMN1; SMN2USP2NOD1NOD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | claimed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | claimed |
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |