Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14026782 | 0.77 | ALDH1A1 (0.61) | ALDH1A1PKMMAPTSMN1; SMN2POLB | |
| SCHEMBL9698214 | 0.75 | KDM4E (0.52) | MAPK1CYP2C9ALDH1A1PKMKMT2A | |
| SCHEMBL9698208 | 0.74 | CYP2C9 (0.62) | MAPK1CYP2C9ALDH1A1KMT2AKDM4E | |
| SCHEMBL14392906 | 0.74 | CYP2C9 (0.71) | MAPK1CYP2C9ALDH1A1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL9697067 | 0.73 | KDM4E (0.50) | MAPK1CYP2C9ALDH1A1PKML3MBTL1 | |
| SCHEMBL14101774 | 0.73 | CYP2C9 (0.64) | MAPK1CYP2C9ALDH1A1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL9697046 | 0.72 | CYP2C9 (0.45) | MAPK1CYP2C9ALDH1A1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL9697041 | 0.72 | CYP2C9 (0.45) | MAPK1CYP2C9ALDH1A1PKMKMT2A | |
| SCHEMBL10297838 | 0.71 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1KMT2AKDM4ELMNA | |
| SCHEMBL9836671 | 0.70 | SIGMAR1 (0.68) | MAPK1CYP2C9ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | claimed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | claimed |
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |