Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692230 | 0.82 | ALDH1A1 (0.65) | SIGMAR1CYP2C9ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6034681 | 0.81 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL10426083 | 0.81 | NR3C2 (0.50) | SIGMAR1CYP2C9ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3324949 | 0.80 | SIGMAR1 (0.74) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL1674212 | 0.80 | SIGMAR1 (0.74) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL14392906 | 0.80 | CYP2C9 (0.71) | CYP2C9ALDH1A1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL9510691 | 0.80 | SIGMAR1 (1.00) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL9663828 | 0.80 | POLB (0.73) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL3712996 | 0.80 | SIGMAR1 (0.73) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 | |
| SCHEMBL3974097 | 0.77 | SIGMAR1 (0.69) | SIGMAR1ALDH1A1MAPK1GFERSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260901-B1 | BENZENESULPHONAMIDES USEFUL AS ANTI-ARRYTHMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0158775-B1 | SUBSTITUTED SULFONAMIDOBENZAMIDES, ANTIARRYTHMIC AGENTS AND COMPOSITIONS THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-04-20 | — | — | EP | disclosed |
| EP-0158775-A1 | Substituted sulfonamidobenzamides, antiarrythmic agents and compositions thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-23 | — | — | EP | disclosed |
| US-4544654-A | Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof | SCHERING A.G. (DE) | 1985-10-01 | — | — | US | disclosed |