Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696278 | 0.78 | IDO1 (0.44) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL10335844 | 0.77 | GCGR (0.38) | GCGRKDM4EMEN1KMT2AGAA | |
| SCHEMBL9696170 | 0.76 | GCGR (0.44) | GCGRKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9697139 | 0.76 | ALDH1A1 (0.41) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL10691696 | 0.73 | ALDH1A1 (0.36) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10693357 | 0.72 | HMGCR (0.46) | KDM4EALDH1A1 | |
| SCHEMBL9753170 | 0.72 | MAPK14 (0.44) | GCGR | |
| SCHEMBL10679732 | 0.68 | HMGCR (0.57) | — | |
| SCHEMBL6241912 | 0.68 | HMGCR (0.57) | — | |
| SCHEMBL8877962 | 0.68 | HMGCR (0.53) | GCGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124453-A | Treatment of corresponding aldehyde with lithium bis(tri-methylsilyl)amide | E. R. SQUIBB & SONS, INC. (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0444532-A1 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5025000-A | Anticholesterol, antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-4751235-A | INHIBIT CHOLESTEROL BIOSINTHESIS | SANDOZ PHARM. CORP. (US) | 1988-06-14 | — | — | US | disclosed |
| EP-0265640-A2 | Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals | SANDOZ AG (CH) | 1988-05-04 | — | — | EP | disclosed |