Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 12/20 | 0.52 |
| ▸ | MME | P08473 | 11/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | KYNU | Q16719 | 1/20 | 0.50 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23881850 | 0.85 | ACE2 (0.50) | ECE1MMEACE2KYNUPRTN3 | |
| SCHEMBL23881683 | 0.83 | MMP8 (0.52) | ECE1MMEACE2KYNU | |
| SCHEMBL15397886 | 0.82 | ACE2 (0.56) | ECE1MMEACE2KYNUPRTN3 | |
| SCHEMBL23881812 | 0.82 | ACE2 (0.52) | ECE1MMEACE2KYNUPRTN3 | |
| SCHEMBL9715281 | 0.81 | ACE2 (0.62) | ECE1MMEACE2KYNU | |
| SCHEMBL9697199 | 0.81 | ACE2 (0.70) | ECE1MMEACE2 | |
| SCHEMBL23881893 | 0.79 | ACE2 (0.48) | ECE1MMEACE2 | |
| SCHEMBL8278084 | 0.79 | ECE1 (0.62) | ECE1MMEACE2 | |
| SCHEMBL23881969 | 0.78 | ACE2 (0.55) | ECE1MMEACE2PRTN3ELANE | |
| SCHEMBL23881970 | 0.78 | MEN1 (0.54) | ECE1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |