Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 10/20 | 0.47 |
| ▸ | ANPEP | P15144 | 9/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 8/20 | 0.47 |
| ▸ | LAP3 | P28838 | 3/20 | 0.47 |
| ▸ | IL1RN | P18510 | 2/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | CPA2 | P48052 | 1/20 | 0.43 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697346 | 0.83 | ERAP1 (0.65) | ERAP1ANPEPERAP2LAP3IL1RN | |
| SCHEMBL9698353 | 0.81 | ANPEP (0.50) | ERAP1ANPEPERAP2LAP3MME | |
| SCHEMBL8890206 | 0.80 | TDP1 (0.56) | — | |
| SCHEMBL7609383 | 0.80 | MMP13 (0.48) | — | |
| SCHEMBL9697234 | 0.76 | ERAP1 (0.59) | ERAP1ANPEPERAP2LAP3IL1RN | |
| SCHEMBL7821394 | 0.75 | KMT2A (0.53) | CPA1MME | |
| SCHEMBL5324039 | 0.75 | SLC1A3 (0.54) | — | |
| SCHEMBL5053304 | 0.74 | GRM3 (0.51) | — | |
| SCHEMBL9696151 | 0.72 | ANPEP (0.72) | ERAP1ANPEPERAP2LAP3MME | |
| SCHEMBL5059960 | 0.72 | GRM3 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |