Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 11/20 | 0.65 |
| ▸ | ERAP2 | Q6P179 | 9/20 | 0.65 |
| ▸ | ANPEP | P15144 | 9/20 | 0.65 |
| ▸ | LAP3 | P28838 | 4/20 | 0.65 |
| ▸ | IL1RN | P18510 | 2/20 | 0.60 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.58 |
| ▸ | CPA1 | P15085 | 4/20 | 0.58 |
| ▸ | CPA2 | P48052 | 4/20 | 0.58 |
| ▸ | CPA4 | Q9UI42 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697234 | 0.92 | ERAP1 (0.59) | ERAP1ERAP2ANPEPLAP3IL1RN | |
| SCHEMBL9646484 | 0.86 | ERAP1 (0.70) | ERAP1ERAP2ANPEPLAP3IL1RN | |
| SCHEMBL9698353 | 0.86 | ANPEP (0.50) | ERAP1ERAP2ANPEPLAP3ENPEP | |
| SCHEMBL9696151 | 0.85 | ANPEP (0.72) | ERAP1ERAP2ANPEPLAP3ENPEP | |
| SCHEMBL9697216 | 0.83 | ERAP1 (0.47) | ERAP1ERAP2ANPEPLAP3IL1RN | |
| SCHEMBL7395511 | 0.82 | MMP2 (0.56) | ERAP1ERAP2ANPEPLAP3CPA1 | |
| SCHEMBL5051239 | 0.82 | ERAP1 (0.58) | ERAP1ERAP2ANPEPLAP3 | |
| SCHEMBL9697220 | 0.80 | ERAP2 (0.58) | ERAP1ERAP2ANPEPLAP3IL1RN | |
| SCHEMBL21067571 | 0.79 | ANPEP (1.00) | ERAP1ERAP2ANPEPLAP3IL1RN | |
| SCHEMBL21067570 | 0.79 | ANPEP (1.00) | ERAP1ERAP2ANPEPLAP3IL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |