Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697217 | 0.88 | HRH1 (0.42) | GRIK1CPB2SMN1; SMN2LOXL2 | |
| SCHEMBL29728626 | 0.80 | MAPT (0.50) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL28014450 | 0.78 | GRIK1 (0.57) | GRIK1PPARGPPARASMN1; SMN2HDAC3 | |
| SCHEMBL7036604 | 0.77 | KEAP1 (0.47) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL9698299 | 0.76 | CA2 (0.39) | GRIK1MAPK1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7644319 | 0.74 | CYP2D6 (0.46) | GRIK1PPARGPPARASMN1; SMN2HDAC3 | |
| SCHEMBL9697710 | 0.73 | GRIK1 (0.44) | GRIK1MAOACPB2HTR2APPARG | |
| SCHEMBL3252245 | 0.72 | GRIK1 (0.51) | GRIK1PPARGPPARASMN1; SMN2HDAC3 | |
| SCHEMBL7653675 | 0.71 | CPA3 (0.47) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL24252168 | 0.71 | GRIK1 (0.50) | GRIK1PPARGPPARASMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | claimed |
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0266978-A2 | Novel antibacterial agents and potentiators of carbapenem antibiotics | MERCK & CO. INC. (US) | 1988-05-11 | — | — | EP | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |