Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947332 | 0.77 | TSHR (0.40) | KMT2ACYP1A2TSHRMAPTHTR2A | |
| SCHEMBL10435405 | 0.73 | POLB (0.39) | KMT2ACYP1A2TSHRSLC6A3HDAC3 | |
| SCHEMBL9709460 | 0.71 | CYP1A2 (0.43) | KMT2ACYP1A2TSHRPOLB | |
| SCHEMBL28061290 | 0.71 | CYP1A2 (0.42) | KMT2ACYP1A2TSHRMAPTHDAC3 | |
| SCHEMBL755810 | 0.70 | KMT2A (0.45) | KMT2ACYP1A2TSHR | |
| SCHEMBL3490295 | 0.70 | DPP8 (0.39) | CYP1A2TSHRTERTMMP2 | |
| SCHEMBL15463430 | 0.70 | CYP1A2 (0.38) | CYP1A2TSHRHDAC3HDAC4HDAC7 | |
| SCHEMBL653721 | 0.70 | POLB (0.38) | KMT2ACYP1A2TSHRSLC6A3HDAC3 | |
| SCHEMBL4906912 | 0.69 | CYP1A2 (0.41) | KMT2ACYP1A2TSHRMAPTSLC6A3 | |
| SCHEMBL2890843 | 0.68 | CYP1A2 (0.39) | KMT2ACYP1A2TSHRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489220-A1 | Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof | AMERICAN CYANAMID COMPANY (US) | 1992-06-10 | — | — | EP | disclosed |