SCHEMBL9699600

SCHEMBL9699600

O=C(O)c1cc2c(cc1Cl)Sc1cc(Cl)c(C(=O)O)cc1S2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
TSHR P16473 2/20 0.48
TP53 P04637 1/20 0.48
CASP1 P29466 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA13 Q8N1Q1 1/20 0.46
CISD1 Q9NZ45 1/20 0.46
CA14 Q9ULX7 1/20 0.46
CA5B Q9Y2D0 1/20 0.46
DAO P14920 2/20 0.43
AKR1C4 P17516 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9698398 1.00 ALDH1A1 (0.48) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL9468883 0.83 ALDH1A1 (0.41) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL9511400 0.82 TSHR (0.34) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL9511243 0.80 SMN1; SMN2 (0.35) ALDH1A1TSHRCASP1SMN1; SMN2CA12
SCHEMBL68449 0.80 ALDH1A1 (0.61) ALDH1A1TSHRTP53CASP1SMN1; SMN2
Hydrochloric Acid SCHEMBL5080692 0.78 ALDH1A1 (0.58) ALDH1A1TSHRTP53CASP1SMN1; SMN2
Hydrochloric Acid SCHEMBL944411 0.78 ALDH1A1 (0.58) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL69107 0.78 CA1 (0.59) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL28534088 0.78 ALDH1A1 (0.58) ALDH1A1TSHRTP53CASP1SMN1; SMN2
SCHEMBL9508181 0.77 KDM4E (0.46) ALDH1A1CASP1AKR1C3TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed