Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813441 | 0.88 | MEN1 (0.38) | — | |
| SCHEMBL9699643 | 0.85 | MEN1 (0.30) | — | |
| SCHEMBL9813460 | 0.84 | CYP4F2 (0.40) | PPARAKDM4EALDH1A1 | |
| SCHEMBL408605 | 0.83 | TAAR1 (0.40) | TAAR1HTR2APPARDPPARAIDO1 | |
| Bromide SCHEMBL9718283 | 0.83 | IDO1 (0.37) | IDO1SIGMAR1 | |
| SCHEMBL9198674 | 0.82 | TAAR1 (0.42) | TAAR1IDO1SIGMAR1MAOB | |
| SCHEMBL9699540 | 0.82 | — | — | |
| SCHEMBL12002859 | 0.79 | DUT (0.40) | TAAR1HTR2APPARDPPARAIDO1 | |
| SCHEMBL9813439 | 0.77 | TAAR1 (0.35) | TAAR1HTR2APPARDPPARAIDO1 | |
| SCHEMBL9566318 | 0.76 | TAAR1 (0.39) | TAAR1IDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106991-A | Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof | E. R. SQUIBB & SONS, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0297768-B1 | ARYLTHIOALKYLPHENYL CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING SAME AND METHOD OF USE | E.R. Squibb & Sons, Inc. (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0400584-A2 | Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof | E.R. SQUIBB & SONS, INC. (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4975452-A | Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof | E. R. SQUIBB & SONS, INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0297768-A1 | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use | E.R. Squibb & Sons, Inc. (US) | 1989-01-04 | — | — | EP | disclosed |
| US-4783473-A | ANTICOAGULANTS, VASODILATORS, BRONCHODILATORS | E. R. SQUIBB & SONS, INC. (US) | 1988-11-08 | — | — | US | disclosed |
| US-4752616-A | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use | E. R. SQUIBB & SONS, INC. (US) | 1988-06-21 | — | — | US | disclosed |